Development of L-Asparaginase Biobetters: Current Research Status and Review of the Desirable Quality Profiles

L-Asparaginase (ASNase) is a vital component of the first line treatment of acute lymphoblastic leukemia (ALL), an aggressive type of blood cancer expected to afflict over 53,000 people worldwide by 2020.More recently, rumchata proof ASNase has also been shown to have potential for preventing metastasis from solid tumors.The ASNase treatment is, ho

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A guide to unsupervised image segmentation of mCT-scanned cellular metals with mixture modelling and Markov random fields

Characterising the structure of cellular metals is a difficult task.The internal structure of cellular metals can be determined using micro-computed tomography (mCT).However, mCT scanning provides digital images in greyscale with various problematic artefacts.In addition, the grey intensity of cellular metals usually varies greatly due to the inter

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Evaluation of acute esophageal radiation-induced damage using magnetic resonance imaging: a feasibility study in mice

Abstract Background Thoracic and head and neck cancer radiation therapy (RT) can cause damage to nearby healthy organs such as the esophagus, causing acute radiation-induced esophageal damage (ARIED).A non-invasive method to detect and monitor ARIED can facilitate optimizing RT to avoid ARIED while improving local tumor control.Current clinical gui

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